Ruth Duncan http://www.ruthduncan.co.uk

Updated August 2017

Recent Reviews HPMA Copolymers

2009 - UPDATE ON THOSE HPMA COPOLYMER ANTICANCER CONJUGATES TRANSFERRED INTO CLINICAL TRIALS

Duncan, R. Development of HPMA Copolymer Anticancer Conjugates: Clinical Experience And Lessons Learnt (2009) In: Vicent, M. J. and Duncan, R. (Eds. Theme Issue: Polymer Therapeutics: Clinical Applications and Challenges for Development.) Adv. Drug Del. Rev.61, 1131-1148.

2010- DISCUSSION REGARDING THE CURRENT STATUS OF HPMA COPOLYMERS AS POTENTIAL DRUG DELIVERY SYSYTEMS AND THEIR FUTURE POTENTIAL?
Duncan, R. and Vicent, M. J. (2010) Do HPMA copolymer conjugates have a future as clinically useful nanomedicines? A critical overview of current status and future opportunities. Adv. Drug Del. Rev., 62, 262-272.

PRECLINICAL SAFETY AND REGULATORY CONSIDERATIONS
Gaspar, R. and Duncan, R. (2009) Polymeric carriers: preclinical safety and the regulatory implications for design and development of polymer therapeutics. In: Vicent, M. J. and Duncan, R. (Eds. Theme Issue: Polymer Therapeutics: Clinical Applications and Challenges for Development. Adv. Drug Del. Rev. 61, 1220-1231. 

SOME KEY REFERENCES

Duncan R (2006) Polymer conjugates as anticancer nanomedicines. Nature Reviews Cancer 6 688-701
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Duncan R (2003) The dawning era of polymer therapeutics. Nature Reviews Drug Discovery 2 (5) 347-360.
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Duncan R and Izzo L (2005) Dendrimer biocompatibility and toxicity. Adv. Drug Del. Rev. 57,2215-2237.
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Duncan R (1992) Drug-Polymer Conjugates: potential for improved chemotherapy.Anti-Cancer Drugs 3, 175-210
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Duncan R, Dimitrijevic S and Evagorou E. (1996) The role of polymer conjugates in te diagnosis and treatment of cancer. S.T.P. Pharma 6,237-263.

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