Ruth Duncan http://www.ruthduncan.co.uk

Updated August 2017

2012 - ENDOCYTOSIS REVIEW

Duncan R and Richardson SWC (2012) Endocytosis and Intracellular Trafficking as Gateways for Nanomedicines Delivery: Opportunities and Challenges. Mol. Pharm. 9, 2380-2402.

Recent Research Papers - ENDOCYTOSIS AND INTRACELLULAR TRAFFICKING

Seib, F.P. Jones, A.T. and Duncan, R. (2006) Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics I. Differential centrifugation fractionation of B16F10 cells and use to study the intracellular fate of HPMA copolymer-doxorubicin. J. Drug Targeting 14, 375-90.

Seib, F.P. Jones, A.T., Duncan, R. (2007) Endocytic behaviour of linear, branched PEI and cationic PAMAM dendrimers in B16F10 melanoma cells, J. Controlled Release, 17, 291-300.

Manunta, M. Izzo, L., Duncan R. and Jones, A.T. (2007) Establishment of subcellular fractionation techniques to monitor the intracellular fate of polymer therapeutics II. Identification of endosomal and lysosomal compartments in HepG2 cell lysates combining a single-step subcellular fractionation with fluorescent imaging. J. Drug Targeting, 15(1): 37–50.

Richardson, S. C. W., Wallom, K.-L., Ferguson, E. L., Deacon, S. P. E., Davies, M. Powell, A. J., Piper, R., and Duncan, R. (2008) The use of fluorescence microscopy to define polymer conjugate localisation to late endocytic compartments in cells that are targets for drug delivery. J. Controlled Release, 127, 1-11

Richardson S.C.W., Pattrick, N.G. Lavignac, N., Ferruti, P. and Duncan, R. (2010) Intracellular fate of bioresponsive poly(amidoamine)s in vitro and in vivo, J. Contr. Rel., 142, 78-88.

SOME KEY REFERENCES

Duncan R (2006) Polymer conjugates as anticancer nanomedicines. Nature Reviews Cancer 6 688-701
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Duncan R (2003) The dawning era of polymer therapeutics. Nature Reviews Drug Discovery 2 (5) 347-360.
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Duncan R and Izzo L (2005) Dendrimer biocompatibility and toxicity. Adv. Drug Del. Rev. 57,2215-2237.
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Duncan R (1992) Drug-Polymer Conjugates: potential for improved chemotherapy.Anti-Cancer Drugs 3, 175-210
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Duncan R, Dimitrijevic S and Evagorou E. (1996) The role of polymer conjugates in te diagnosis and treatment of cancer. S.T.P. Pharma 6,237-263.

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